Connectomics Workshop

April 17–19, 2026

Decoding the human brain’s circuitry

Connectomics Workshop

About PL Neuro Workshops

PL Neuro workshops are a series of small, invite-only meetings whose purpose is to accelerate the development of next generation technologies – like neural augmentation and human-like AI – in a manner that is targeted to benefit humanity. Toward this goal, PL Neuro workshops bring together a deliberately cross-disciplinary group of scientists, entrepreneurs, venture capitalists, and philanthropists with technical expertises across multiple disciplines of neuroscience and AI.

The PL Connectomics Workshop 2026:

Decoding the human brain’s circuitry

Connectomics is approaching an inflection point. Scaling trends suggest a synapse-resolution whole human brain connectome is technically feasible by 2049 — but recent advances in imaging, data processing, and molecular techniques suggest a far more aggressive timeline is now within reach.

This workshop brings together a deliberately cross-disciplinary group of connectomics researchers, AI scientists, engineers, funders, and entrepreneurs to align around a massively ambitious goal: decoding the human brain’s circuitry within the next ten years — and producing a consensus roadmap for how to get there.

The downstream value is concrete: human-like artificial intelligence, 1-to-1 brain emulation, precision treatments for brain disorders, and a rigorous science of biological intelligence and conscious experience. Realizing this future requires moving the field from basic science to an industrial-grade, human-centric initiative.

The workshop is built around four driving questions:

  1. Why should we build human scale connectomics?
  2. What is the technical and logistical roadmap for human scale brain maps?
  3. How do we translate human brain maps to achieve our targeted endpoints?
  4. How do we structure the field to support accelerated connectomics?

The Connectomics Workshop is part of the PL Neuro series — Protocol Labs’ initiative to accelerate frontier science at the intersection of neuroscience, AI, and human flourishing.

Schedule

A high-level view of the agenda. Sessions are designed for collaborative, working discussions.

Friday, April 17 — Arrival & Opening
8:00 pm – 10:00 pm
Welcome Session & Keynotes
📍 Great Hall

Welcome remarks from Sean and David, followed by keynote talks from Sebastian Seung and Moritz Helmstaedter.

Saturday, April 18 — Full Workshop Day
9:00 am – 10:15 am
Session 1: Why should we build human scale connectomics?
📍 Great Hall + Breakouts

Plenary session followed by breakout discussions focused on defining critical datasets.

10:45 am – 12:00 pm
Session 2: What is the technical and logistical roadmap for human scale brain maps?
📍 Great Hall + Breakouts

Plenary session and breakouts exploring approaches to scaling validation and accuracy.

1:15 pm – 2:30 pm
Session 3: Unconference
📍 Great Hall & Breakout Rooms

Participant-led sessions based on selected topics.

Sunday, April 19 — Final Workshop Day & Departures
9:00 am – 10:15 am
Session 4: How do we translate human brain maps to achieve our targeted endpoints?
📍 Great Hall + Breakouts

Plenary and breakout discussions.

10:45 am – 12:00 pm
Session 5: How do we structure the field to support accelerated connectomics?
📍 Great Hall + Breakouts

Final working session and synthesis.

Participants

58 cross-disciplinary researchers, engineers, funders, and founders.

Aatmik Mallya
Aatmik Mallya
Anthropic
Adam Marblestone
Adam Marblestone
Convergent Research
Albert Cardona
Albert Cardona
MRC Laboratory of Molecular Biology
Alipasha Vaziri
Alipasha Vaziri
Rockefeller University
Allison Duettman
Allison Duettman
Foresight Institute
Amy Bernard
Amy Bernard
Kavli Foundation
Andreas Tolias
Andreas Tolias
Stanford University
Andrew Payne
Andrew Payne
E11 Bio
Andrew Woo
Andrew Woo
Protocol Labs
Bobby Kasthuri
Bobby Kasthuri
Argonne National Laboratory
Brigid Maloney
Brigid Maloney
Rockefeller University, Icahn School of Medicine at Mount Sinai
Cathryn Cadwell
Cathryn Cadwell
University of California San Francisco
Clay Reid
Clay Reid
Allen Institute
Davi Bock
Davi Bock
University of Vermont
David Markowitz
David Markowitz
Protocol Labs, ex-IARPA
Dileep George
Dileep George
Astera Institute